Moving from universal to selective prevention: results of a web-based early intervention for PTSD

Joanne MouthaanThis is a post by Joanne Mouthaan. As a PhD candidate, Joanne conducted a large prospective longitudinal trial of mental health in traumatic injury patients in Amsterdam. Now in the final stage of her thesis, she is working as a lecturer at the Department of Clinical and Health Psychology of Leiden University, The Netherlands.

Our team’s goal is to gain more insight into a) the incidence and development of mental health problems after injury, b) possible bio/psycho/social factors contributing to these problems, and c) prevention of mental health problems by intervening early. From 2005 to 2010, we recruited approximately 900 patients from two level-1 trauma centers (the Academic Medical Center and the VU University Medical Center). Regarding the issue of prevention, we developed a web-based early psychological intervention called Trauma TIPS, the main subject of this post.

Traumatic injury and PTSD

Around the world, traumatic injury is one of the most common traumatic events, accounting for 9% of global mortality. Because of its high incidence, injuries cause millions of people to experience (temporary or permanent) disabilities on a yearly basis, including mental health problems (see http://www.who.int/topics/injuries/en/). PTSD develops in 10-20% of injury patients. Therefore, prevention of PTSD has been mentioned by some as the holy grail of trauma research.

Using CBT in prevention

Up to now, only interventions based on cognitive behavioral therapy (CBT) have proven effective in preventing chronic PTSD. Mostly, this concerned early treatment (3-5 sessions) of acute (posttraumatic) stress symptoms. It is still unclear whether a single session of CBT-techniques could also prevent PTSD. Below are the recently published results of our brief self-guided Internet intervention, Trauma TIPS [1] (see Figure 1) . The aim of the program was to decrease acute distress, anxiety, and arousal, which are known to predict PTSD, and to prevent the onset of PTSD symptoms through various CBT-techniques. eHealth interventions are nowadays considered cost-effective and increasingly feasible, as global Internet use is growing exponentially. Although studies showed Internet-based CBT programs to be successful in the treatment of PTSD, little evidence exists whether these programs may prevent PTSD.

Trauma Tips

Figure 1. Screenshot of the intervention

Study design and methods

Our study examined whether Trauma TIPS prevents the onset of PTSD, anxiety and depression in injury patients compared to care as usual. In addition, we evaluated whether Trauma TIPS led to a decrease in mental health care utilization during the first year after injury. Adult, level 1 trauma center patients were randomly assigned to receive the fully automated Trauma TIPS Internet intervention (n=151) or to receive no early intervention (n=149).

Trauma TIPS consisted of psychoeducation, in vivo exposure, and stress management techniques (for more information on the intervention, see [2]). Both groups were free to use care as usual. PTSD symptom severity was assessed at 1, 3, 6, and 12 months post injury with a clinical interview (Clinician-Administered PTSD Scale) by blinded trained interviewers and self-report instrument (Impact of Event Scale-Revised). Secondary outcomes were acute anxiety and arousal (assessed online), self-reported depressive and anxiety symptoms (Hospital Anxiety and Depression Scale), and mental health care utilization. Intervention usage was documented.

Intervention usage

Of the total intervention group, 42% (n=63) logged in once, 36% (n=54) logged in multiple times (mean=3.6, s.d.=3.5), but 22.5% (n=34, i.e., non-users) did not log in at all. On average, patients logged in 1.7 times (s.d.=2.5), for 20.8 minutes (s.d.=26.3). There were no differences in study dropout or outcome measures between nonusers and users of the intervention, or between patients with a single log-in versus multiple log-ins.

Main outcomes

The results of our mixed model analyses showed no significant main effects of the intervention on symptoms of PTSD, anxiety or depression during the first year following injury. Both groups recovered from their symptoms equally over time with no significant group differences. PTSD rates declined from 9.2% (n=21) at 1 month to 4.5% (n=6) at 12 months, also with no significant differences between patients with and without intervention. The groups showed no differences in mental health care usage.

Latent subgroups

Using post hoc latent growth mixture model analysis (LGMM), we examined whether the intervention could be beneficial to a specific subgroup of patients. This revealed 2 latent subgroups of patients with high initial (baseline) PTSD symptoms versus low symptoms. The main difference was between the high symptom groups: high symptom patients in the intervention condition showed a significant decrease in PTSD symptoms over time (p<0.001), but high symptom patients in the control condition did not (p=0.32).

Conclusion

We did not find any main effects of the intervention on symptoms of PTSD, depression or anxiety. An important finding is that participants were reluctant to use the intervention. In fact, one in five patients in the intervention group lacked any exposure to the intervention. Based on these results, there are currently no indications that offering a voluntary, information-based prevention program via the Internet to unselected injury victims is useful in preventing PTSD symptoms.

It is important to target future comparable Internet-based early interventions at individuals with high initial symptoms, since Trauma TIPS did show effects in a latent subgroup of participants with high PTSD symptoms at baseline. Future research may focus on innovative strategies to increase intervention usage. Moreover, it is time to move from universal to selective prevention, targeting high-risk individuals who are more likely to benefit from the intervention.

Main references

[1] Mouthaan J, Sijbrandij M, de Vries GJ, Reitsma JB, van de Schoot R, Goslings JC, Luitse JS, Bakker FC, Gersons BP, & Olff M (2013). Internet-based early intervention to prevent posttraumatic stress disorder in injury patients: randomized controlled trial. Journal of medical Internet research, 15 (8) PMID: 23942480

[2] Mouthaan J, Sijbrandij M, Reitsma JB, Gersons BP, Olff M. Internet-based prevention of posttraumatic stress symptoms in injured trauma patients: design of a randomized controlled trial. European Journal of Psychotraumatology 2011 Nov 4;2(8294):DOI: 10.3402/ejpt.v2i0.8294.

For more information, please contact Joanne at j.mouthaan@amc.nl or  nl.linkedin.com/in/joannemouthaan/.

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